Searchable abstracts of presentations at key conferences in endocrinology

ea0056p128 | Endocrine tumours and neoplasia | ECE2018

Ghrelin is overexpressed in adrenal cancers and stimulates proliferation and migration of ACC cell line.

Komarowska Hanna , Rucinski Marcin , Tyczewska Marianna , Sawicka-Gutaj Nadia , Szyszka Marta , Hernik Aleksandra , Klimont Anna , Milecka Paulina , Migasiuk Laura , Biczysko Mateusz , Idasiak-Piechocka Ilona , Karczewski Marek , Czarnywojtek Agata , Ruchala Marek

Purpose: Adrenal cancers are relatively rare, but they have poor prognosis. IGF2 has been confirmed as a factor of adrenal tumors development. Recent data indicate that ghrelin may be an essential factor in cancerogenesis. The aim of our study was to assess ghrelin expression in adrenal tumors, and to investigate the relationship between ghrelin, IGF2 and the clinicopathological characteristics. We also investigated the influence of ghrelin on adenocarcinoma cell line prolifer...